Ole Miss vs. Georgia Southern odds and picks for college football Week 4

No. 4 Ole Miss vs. Georgia Southern will kick off on Saturday at 7:45 p.m. ET. The Ole Miss Rebels will host the Georgia Southern Eagles in what will likely be a one-sided affair in favor of Ole Miss.

Oddsmakers, experts, and analytical models all agree that the Rebels are favored to win this one. All Georgia Southern can do is prove everyone wrong in this week 4 game.

Ole Miss (3-0) is coming off a 40-6 win over Wake Forest. Meanwhile, Georgia Southern (2-1) is coming off a 42-14 win over SC State.

Ole Miss vs. Georgia Southern score prediction

Ole Miss vs. Georgia Southern is not likely to be a close game. However, it is also not projected to be the biggest blowout of the week. While Georgia Southern is an underdog, the Eagles are not a helpless team. They won their last two games.

Ole Miss fans should watch to see if Ole Miss can continue to prove itself on defense. Ole Miss has held its opponents to nine points total in three games. The team had a 76-0 shutout over Furman in week 1, a 52-3 win over Middle Tennessee in week 2, and a 40-6 win over Wake Forest in week 3.

Georgia Southern's only path to victory is to make no mistakes on offense. Ole Miss has dominated defensively this season, so Georgia Southern cannot waste any drives.

Experts agree that Ole Miss vs. Georgia Southern should be a victory for the Rebels, but they are divided in predicting how close the game will be. However, the general consensus is that while Georgia Southern is strong enough to put a few points up, Ole Miss will overwhelm the Eagles and pull ahead by several touchdowns.

Ole Miss vs. Georgia Southern point spread prediction

The point spread at DraftKings for this game is currently set at 35.5 points. That turns out to be a nearly perfect line based on the predictions by experts. The score difference in the prediction is 35 points. So, if that turns out to be accurate, bettors should wager on Georgia Southern's side of the point spread.

If Georgia Southern can score at least two touchdowns, betting on the Eagles' side of the spread makes sense. If not, bet on the Rebels' side. Either way, it is a close line that could go either way.

What time is Ole Miss vs. Georgia Southern game on?

This matchup between Ole Miss and Georgia Southern will take place at 7:45 p.m. ET on Saturday. The game will be hosted by Ole Miss at Vaught-Hemingway Stadium in Oxford, Mississippi.

The game will be broadcast nationally on the SEC Network with Tom Hart as the play-by-play announcer. Fans without access to cable can stream the game on Fubo TV.