Clemson vs. Florida State Prediction & Betting Tips October 5 | College Football Week 6 

The No. 15 Clemson Tigers will travel to Tallahassee this Saturday for a Week 6 matchup against the Florida State Seminoles. Clemson is rolling after their season-opening loss to the No. 1 Georgia Bulldogs, posting a 3-1 record through four games. Florida State, meanwhile, has been struggling mightily since the start of the season, with a 1-4 record after their first five games.

The Tigers enter Week 6 off a dominant 40-14 win over the Stanford Cardinal, and is one of the hottest teams in college football. Clemson has scored 40 points, 59 points and 66 points, respectively, in their last three games, outscoring their opponents 165-69 during that stretch. While many wrote Clemson off after an embarrassing Week 1 performance, the Tigers have bounced back in a big way and will look to carry that momentum into this week's matchup.

Entering the 2024 season, there was only one direction Florida State could go following a 13-1 campaign last season: Down. And the Seminoles wasted no time going in that direction. Florida State opened the season as the No. 10-ranked team in the country but was upset in Ireland by Georgia Tech in Week 0. Going into Week 1, the Seminoles were widely expected to bounce back versus Boston College, entering the contest as 16.5 point favorites, but fell to 0-2 after a 28-13 loss.

Things kept getting worse for FSU as they suffered their third straight loss versus Memphis before picking up their first win of the season versus Cal. Last time out, the Seminoles suffered a 42-16 loss against SMU, leaving them 1-4 for the season.

Clemson vs. FSU: Prediction

Florida State entering the week as 15.5 point underdogs feels like the sportsbooks are still looking for a glimpse of the Seminoles of old, despite the massive margin. This one is an easy prediction: Clemson by a mile.

The Tigers have looked like a playoff contender over the last three weeks, something that should continue, given the stellar play of Clemson's high-powered offense. With Florida State looking as low as a team could get, Clemson should run away with this one as they continue to build their playoff resume following their Week 1 loss.

Clemson vs. FSU: Betting Tips

Tip 1: Clemson Tigers -14.5 (-110)

Tip 2: Total Points Over 47.5 (-115)

Tip 3: Cade Klubnik Over 1.5 Passing TDs (-190)

Clemson vs. FSU: Head-to-Head

The Clemson-FSU rivalry will see its 37th matchup this weekend, as Clemson looks to add another win to their side of the series. The Seminoles lead the overall head-to-head record 21-15 and claimed a win in the rivalry last season, topping the Tigers 31-24.

The games between both schools go back to 1970, with Florida State winning three of its first four matchups. The Seminoles also have the longest win streak of the series, winning 11 straight games from 1992-2002.

Will Clemson continue to stack up the wins or can the Seminoles try to get their season back on track with an upset win? Let us know your thoughts in the comments section below.